Field Evaluation of Preventive Efficacy of Monthly Multimodal Prophylactic Treatment (Milbactor® and Vectra® 3D) against Dirofilaria spp. in Dogs

Dirofilaria immitis and repens are mosquito-borne pathogens responsible for dirofilariasis in humans animals. Their transmission spread depend on the activity of vectors frequency hosts a given area. Here, we investigated efficacy monthly multimodal prophylactic (MMP) strategy against canine Corsica Island (France). The study was conducted as evidence an trial which eighty dogs were divided into two groups: (i) one test group consisted 25 under MMP [per-os administration 1.5 tablets milbemycin-oxime-praziquantel (Milbactor®) topical line-on application 3.6 mL solution dinotefuran-permethrin-pyriproxyfen (Vectra® 3D)] (ii) control different real-life treatments (RLP) based use ectoparasiticides (different formulations: deltamethrin, fluralaner, fipronil) and/or macrocyclic lactone-based products (milbemycin-oxime/praziquantel, milbemycin-oxime, moxidectin) during period from June to October 2017. All animals followed up year, with blood collected at day 0, follow-up 6 12 months. Samples tested spp. by species-specific qPCR. At end study, no new case infection detected group. However, cumulative incidence 16.4% (n = 9; p 0.027) data illustrate that, contrast RLP treatment, failed protect least dogs, simultaneous milbemycin oxime-praziquantel efficiently protects high-risk area infection.